IGF-1 DES

DES IGF-1 is the shorter version of the IGF-1 chain. It is five (5) times more powerful than IGF-LR3 and ten (10) times more powerful than regular base IGF-1. The half-life for DES is about 20-30 minutes, which means this is a very delicate chain. Therefore, administration should only be done at the site where you want to see muscle growth. DES has the ability to stimulate muscle hyperplasia better than LR3. In simple terms, it’s best used for site injections, rather than overall growth.

In addition, DES is known to bind to receptors that have been deformed by lactic acid, which is often present during workouts. This allows the DES to attach itself to a mutated receptor and signal tissue growth during training. DES can be used longer and more frequently than LR3. It has been rumored that the first official use of IGF-1 as a performance enhancing drug was in the early 1990s by then-Mr. Olympia Dorian Yates, which at the time was considered an extremely rare and expensive drug to obtain, after which its use quickly spread amongst the bodybuilding community.

DESCRIPTION

IGF-1 DES (reported as des(1-3)IGF-I in scientific studies) is a truncated version of naturally occurring IGF-1. The 70 amino acid form of activated IGF-1 is essential for normal human growth and development and acts via IGF-1 receptors to exert an anabolic effect to build muscle, which is why IGF-1 is important in bodybuilding [1]. Low IGF-1 levels are linked to poor growth and a number of metabolic disorders [2]. Multiple tissues inside the body produce IGF-1 and its site of synthesis affects its function. The majority of IGF-1 is made by the liver and is transported to other tissues in the bloodstream, where it acts as an endocrine hormone [3]. Importantly, IGF-1 is a central growth hormone that controls the anabolic growth promoting effect of growth hormone. It also has a growth hormone independent growth-stimulating effect, which is optimised when combined with growth hormone [4]. IGF-1 DES has been specially formulated to lack three amino acids from the end of natural IGF-1, which increases its potency to around ten-fold higher when compared to regular IGF-1 [5]. This increase in potency is due to the fact that IGF-1 DES does not bind to IGF-binding proteins like IGF-1 [6]. Usually, IGF-binding proteins immediately block the growth-promoting activities of IGF-1, but they are unable to bind and block IGF-1 DES. This means that the peptide is free to promote muscle and bone growth and repair and smooth muscle survival [7, 8]. IGF-I DES has been shown to stimulate body growth in a range of tissues in multiple animal studies [9]. Animal studies have also shown that carcass fat was reduced alongside muscle gains [9]. In diabetic animals the modified peptide demonstrated effects throughout the alimentary tract and led to improvements in nutrient uptake [10]. Although no human clinical trials using IGF-1 DES have been carried out, studies have uncovered that the peptide is naturally found in the human brain and brain cell studies have shown that it can protect against brain damage and that it promotes brain growth .

DOSAGES:

IGF-1 DES has a short half-life and is degraded within 5 minutes of administration in humans [13]. The short half-life means that IGF-1 DES 1 mg should be dosed intramuscularly. Up to 100 mcg can be dosed per day and this should be split between either two or four muscles pre-workout. A standard IGF-1 cycle should last four weeks and should be stacked with an anabolic androgenic steroid for optimal results.

Side effects of IGF-1 DES may include headaches and nausea since the peptide can induce a hypoglycaemic state. High levels of this hormone have also been shown to promote organ enlargement, so never exceed the recommended dose of 100 mcg per day.

Mixing and our recommended dosage

You inject 1ml water into the vial of IGF1-DES from the water vial. 1 full syringe is 1ml. You then wait for the vial powder content to dissolve ON ITS OWN. DO NOT SHAKE THE VIAL TO MIX POWDER. Once dissolved and clear in colour. You inject 0.05 (50mcg) into the muscle bilaterally. So this means directly into the muscle and bilaterally meaning you split the 50mcg into 25mcg and 25mcg and inject into the corresponding body part on the alternative side of the body. EG. Inject into the bicep on right arm 25mcg and then 25mcg other half of the body as an example. A vial should last 18 to 20 days.